Development of magneto-plasmonic nanoparticles for multimodal image-guided therapy to the brain

Asahi Tomitaka, Hamed Arami, Andrea Raymond, Adriana Yndart, Ajeet Kaushik, Rahul Dev Jayant, Yasushi Takemura, Yong Cai, Michal Toborek, Madhavan Nair

    抄録

    Magneto-plasmonic nanoparticles are one of the emerging multi-functional materials in the field of nanomedicine. Their potential for targeting and multi-modal imaging is highly attractive. In this study, magnetic core/gold shell (MNP@Au) magneto-plasmonic nanoparticles were synthesized by citrate reduction of Au ions on magnetic nanoparticle seeds. Hydrodynamic size and optical properties of magneto-plasmonic nanoparticles synthesized with the variation of Au ions and reducing agent concentrations were evaluated. The synthesized magneto-plasmonic nanoparticles exhibited superparamagnetic properties, and their magnetic properties contributed to the concentration-dependent contrast in magnetic resonance imaging (MRI). The imaging contrast from the gold shell part of the magneto-plasmonic nanoparticles was also confirmed by X-ray computed tomography (CT). The transmigration study of the magneto-plasmonic nanoparticles using an in vitro blood-brain barrier (BBB) model proved enhanced transmigration efficiency without disrupting the integrity of the BBB, and showed potential to be used for brain diseases and neurological disorders.

    本文言語英語
    ページ(範囲)764-773
    ページ数10
    ジャーナルNanoscale
    9
    2
    DOI
    ジャーナル掲載日出版済み - 2017 1 14

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    Nanoparticles
    Imaging techniques
    Brain
    Gold
    Ions
    Medical nanotechnology
    Magnetic cores
    Functional materials
    Reducing agents
    Magnetic resonance
    Tomography
    Seed
    Magnetic properties
    Hydrodynamics
    Optical properties
    X rays

    ASJC Scopus subject areas

    • Materials Science(all)

    これを引用

    Tomitaka, A., Arami, H., Raymond, A., Yndart, A., Kaushik, A., Jayant, R. D., ... Nair, M. (2017). Development of magneto-plasmonic nanoparticles for multimodal image-guided therapy to the brain. Nanoscale, 9(2), 764-773. DOI: 10.1039/c6nr07520g

    Development of magneto-plasmonic nanoparticles for multimodal image-guided therapy to the brain. / Tomitaka, Asahi; Arami, Hamed; Raymond, Andrea; Yndart, Adriana; Kaushik, Ajeet; Jayant, Rahul Dev; Takemura, Yasushi; Cai, Yong; Toborek, Michal; Nair, Madhavan.

    :: Nanoscale, 巻 9, 番号 2, 14.01.2017, p. 764-773.

    研究成果: ジャーナルへの寄稿記事

    Tomitaka, A, Arami, H, Raymond, A, Yndart, A, Kaushik, A, Jayant, RD, Takemura, Y, Cai, Y, Toborek, M & Nair, M 2017, 'Development of magneto-plasmonic nanoparticles for multimodal image-guided therapy to the brain' Nanoscale, 巻 9, 番号 2, pp. 764-773. DOI: 10.1039/c6nr07520g
    Tomitaka A, Arami H, Raymond A, Yndart A, Kaushik A, Jayant RD その他. Development of magneto-plasmonic nanoparticles for multimodal image-guided therapy to the brain. Nanoscale. 2017 1 14;9(2):764-773. 利用可能場所, DOI: 10.1039/c6nr07520g

    Tomitaka, Asahi; Arami, Hamed; Raymond, Andrea; Yndart, Adriana; Kaushik, Ajeet; Jayant, Rahul Dev; Takemura, Yasushi; Cai, Yong; Toborek, Michal; Nair, Madhavan / Development of magneto-plasmonic nanoparticles for multimodal image-guided therapy to the brain.

    :: Nanoscale, 巻 9, 番号 2, 14.01.2017, p. 764-773.

    研究成果: ジャーナルへの寄稿記事

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