Two-dimensional simulation of the flow behavior of a single deformable red blood cell suspension through a stenosed microvessel

Toru Hyakutake, Tomoaki Hongo

    Abstract

    We simulated the flow behavior of a single red blood cell (RBC) passing through a two-dimensional stenosed microvessel. Blood flow was computed using the lattice Boltzmann method, and the fluid-membrane interaction between the flow field and deformable RBC was incorporated using the immersed boundary method. The vessel diameter and length are 20 and 50 μm, respectively. Two semicircular stenoses were arranged on the upper and lower walls. We investigated the influence of upstream RBC position of vessel width direction and inclination angle against the main flow on RBC deformation and flow resistance when the RBC flowed through the stenosis. The simulation results indicated two flow patterns depending on the upstream position and inclination angle. When the upstream position was near the vessel wall, the average flow resistance increased due to RBC migration to the vessel center. By contrast, when the upstream position was near the vessel center and the inclination angle against the main flow was 90°, the flow resistance increased due to the large RBC deformation. These results can assist in understanding the processes of circulatory diseases with stenosis.

    Original languageEnglish
    Pages (from-to)1-12
    Number of pages12
    JournalJournal of Biomechanical Science and Engineering
    Volume9
    Issue number3
    DOIs
    StatePublished - 2014

    Fingerprint

    Blood
    Cells
    Flow patterns
    Flow fields
    Membranes
    Fluids

    Keywords

    • Flow resistance
    • Lattice Boltzmann method
    • Red blood cell
    • Stenosed microvessel

    ASJC Scopus subject areas

    • Biomedical Engineering

    Cite this

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    title = "Two-dimensional simulation of the flow behavior of a single deformable red blood cell suspension through a stenosed microvessel",
    keywords = "Flow resistance, Lattice Boltzmann method, Red blood cell, Stenosed microvessel",
    author = "Toru Hyakutake and Tomoaki Hongo",
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    doi = "10.1299/jbse.14-00202",
    volume = "9",
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    journal = "Journal of Biomechanical Science and Engineering",
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    AU - Hyakutake,Toru

    AU - Hongo,Tomoaki

    PY - 2014

    Y1 - 2014

    N2 - We simulated the flow behavior of a single red blood cell (RBC) passing through a two-dimensional stenosed microvessel. Blood flow was computed using the lattice Boltzmann method, and the fluid-membrane interaction between the flow field and deformable RBC was incorporated using the immersed boundary method. The vessel diameter and length are 20 and 50 μm, respectively. Two semicircular stenoses were arranged on the upper and lower walls. We investigated the influence of upstream RBC position of vessel width direction and inclination angle against the main flow on RBC deformation and flow resistance when the RBC flowed through the stenosis. The simulation results indicated two flow patterns depending on the upstream position and inclination angle. When the upstream position was near the vessel wall, the average flow resistance increased due to RBC migration to the vessel center. By contrast, when the upstream position was near the vessel center and the inclination angle against the main flow was 90°, the flow resistance increased due to the large RBC deformation. These results can assist in understanding the processes of circulatory diseases with stenosis.

    AB - We simulated the flow behavior of a single red blood cell (RBC) passing through a two-dimensional stenosed microvessel. Blood flow was computed using the lattice Boltzmann method, and the fluid-membrane interaction between the flow field and deformable RBC was incorporated using the immersed boundary method. The vessel diameter and length are 20 and 50 μm, respectively. Two semicircular stenoses were arranged on the upper and lower walls. We investigated the influence of upstream RBC position of vessel width direction and inclination angle against the main flow on RBC deformation and flow resistance when the RBC flowed through the stenosis. The simulation results indicated two flow patterns depending on the upstream position and inclination angle. When the upstream position was near the vessel wall, the average flow resistance increased due to RBC migration to the vessel center. By contrast, when the upstream position was near the vessel center and the inclination angle against the main flow was 90°, the flow resistance increased due to the large RBC deformation. These results can assist in understanding the processes of circulatory diseases with stenosis.

    KW - Flow resistance

    KW - Lattice Boltzmann method

    KW - Red blood cell

    KW - Stenosed microvessel

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