State-dependent learning produced by chlordiazepoxide and its transfer at different dose levels

Sachio Fukuda, Shinkuro Iwahara

  • 3 Citations

Abstract

In Experiment I, the rat was given 15 mg/kg of chlordiazepoxide (CDP) and trained on a black-white discrimination task, motivated by electric shocks; the same animal, when given saline, was treated similarly with the reversed cue relationship on different and usually alternate sessions. Training was continued until a learning criterion under both drug and saline states and then tested with only one of five testing CDP doses (2.5, 5, 10, 20 and 25 mg/kg). During training, the rat made more errors under drug than under saline but there were little differences in starting and running times at least during the last sessions. In the transfer test, choice responses showed a bi-directional gradient around the training dose as in stimulus generalization gradient. Experiment II was identical to Experiment I, except that the same drug was tested at all five transfer doses and the resulting transfer gradient was a simple monotonic increasing function of dose levels. Discrepancy between the two experiments was discussed. © 1976 Springer-Verlag.

Original languageEnglish
Pages (from-to)193-198
Number of pages6
JournalPsychopharmacology
Volume48
Issue number2
DOIs
StatePublished - 1976 Jan 1
Externally publishedYes

Fingerprint

Chlordiazepoxide
Learning
Transfer (Psychology)
Stimulus Generalization
Cues
Discrimination (Psychology)

Keywords

  • Chlordiazepoxide
  • Drug stimulus
  • Drug transfer test
  • Drug-state dependency
  • Drug-state discrimination
  • Stimulus generalization gradient

ASJC Scopus subject areas

  • Pharmacology

Cite this

State-dependent learning produced by chlordiazepoxide and its transfer at different dose levels. / Fukuda, Sachio; Iwahara, Shinkuro.

In: Psychopharmacology, Vol. 48, No. 2, 01.01.1976, p. 193-198.

Research output: Contribution to journalArticle

Fukuda, Sachio; Iwahara, Shinkuro / State-dependent learning produced by chlordiazepoxide and its transfer at different dose levels.

In: Psychopharmacology, Vol. 48, No. 2, 01.01.1976, p. 193-198.

Research output: Contribution to journalArticle

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