Preparation of bicelles using the semi-spontaneous method

Yuki Watanabe, Kenji Aramaki, Yuya Kadomatsu, Ken Tanaka, Yoshikazu Konno

Abstract

Bicelles are smaller than liposomes and are expected to show greater efficiency for transdermal drug delivery. Formulating bicelles with low-cost materials and avoiding complicated formulation processes would extend their application fields. In this study, lecithin and poly(oxyethylene) sorbitan monooleate (Tween80) were dissolved in 1,3-butanediol, and the mixture was then dispersed in water by ultrasonication. Using this semispontaneous method, we obtained bicelles that were stable for up to 180 days.

Original languageEnglish
Pages (from-to)558-560
Number of pages3
JournalChemistry Letters
Volume45
Issue number5
DOIs
StatePublished - 2016

Fingerprint

Lecithin
Liposomes
Drug delivery
Costs
Water

Keywords

  • Bicelle
  • Lecithin
  • Semi-spontaneous method

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Watanabe, Y., Aramaki, K., Kadomatsu, Y., Tanaka, K., & Konno, Y. (2016). Preparation of bicelles using the semi-spontaneous method. Chemistry Letters, 45(5), 558-560. DOI: 10.1246/cl.160118

Preparation of bicelles using the semi-spontaneous method. / Watanabe, Yuki; Aramaki, Kenji; Kadomatsu, Yuya; Tanaka, Ken; Konno, Yoshikazu.

In: Chemistry Letters, Vol. 45, No. 5, 2016, p. 558-560.

Research output: Contribution to journalArticle

Watanabe, Y, Aramaki, K, Kadomatsu, Y, Tanaka, K & Konno, Y 2016, 'Preparation of bicelles using the semi-spontaneous method' Chemistry Letters, vol 45, no. 5, pp. 558-560. DOI: 10.1246/cl.160118
Watanabe Y, Aramaki K, Kadomatsu Y, Tanaka K, Konno Y. Preparation of bicelles using the semi-spontaneous method. Chemistry Letters. 2016;45(5):558-560. Available from, DOI: 10.1246/cl.160118

Watanabe, Yuki; Aramaki, Kenji; Kadomatsu, Yuya; Tanaka, Ken; Konno, Yoshikazu / Preparation of bicelles using the semi-spontaneous method.

In: Chemistry Letters, Vol. 45, No. 5, 2016, p. 558-560.

Research output: Contribution to journalArticle

@article{1a0da657ee3243968eccba90996d8a4f,
title = "Preparation of bicelles using the semi-spontaneous method",
keywords = "Bicelle, Lecithin, Semi-spontaneous method",
author = "Yuki Watanabe and Kenji Aramaki and Yuya Kadomatsu and Ken Tanaka and Yoshikazu Konno",
year = "2016",
doi = "10.1246/cl.160118",
volume = "45",
pages = "558--560",
journal = "Chemistry Letters",
issn = "0366-7022",
publisher = "Chemical Society of Japan",
number = "5",

}

TY - JOUR

T1 - Preparation of bicelles using the semi-spontaneous method

AU - Watanabe,Yuki

AU - Aramaki,Kenji

AU - Kadomatsu,Yuya

AU - Tanaka,Ken

AU - Konno,Yoshikazu

PY - 2016

Y1 - 2016

N2 - Bicelles are smaller than liposomes and are expected to show greater efficiency for transdermal drug delivery. Formulating bicelles with low-cost materials and avoiding complicated formulation processes would extend their application fields. In this study, lecithin and poly(oxyethylene) sorbitan monooleate (Tween80) were dissolved in 1,3-butanediol, and the mixture was then dispersed in water by ultrasonication. Using this semispontaneous method, we obtained bicelles that were stable for up to 180 days.

AB - Bicelles are smaller than liposomes and are expected to show greater efficiency for transdermal drug delivery. Formulating bicelles with low-cost materials and avoiding complicated formulation processes would extend their application fields. In this study, lecithin and poly(oxyethylene) sorbitan monooleate (Tween80) were dissolved in 1,3-butanediol, and the mixture was then dispersed in water by ultrasonication. Using this semispontaneous method, we obtained bicelles that were stable for up to 180 days.

KW - Bicelle

KW - Lecithin

KW - Semi-spontaneous method

UR - http://www.scopus.com/inward/record.url?scp=84966361888&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84966361888&partnerID=8YFLogxK

U2 - 10.1246/cl.160118

DO - 10.1246/cl.160118

M3 - Article

VL - 45

SP - 558

EP - 560

JO - Chemistry Letters

T2 - Chemistry Letters

JF - Chemistry Letters

SN - 0366-7022

IS - 5

ER -