Preparation and characterization of newly developed matrix using functional γ-Fe2O3 nanoparticles for mass spectrometry in small molecules

Shota Morimoto, Tomoya Ishikawa, Kuminori Hyodo, Takahiro Yamazaki, Shu Taira, Koichi Tsuneyama, Yuko Ichiyanagi

Abstract

Iron oxide magnetic nanoparticles were prepared by our original chemical wet method. These particles were functionalized by modification of amino groups and other molecules for biomedical application. The obtained particles were characterized by X-ray diffraction, fourier transform infrared spectroscopy (FT-IR), and magnetization measurements, and then local structures were analyzed using X-ray absorption near edge structure (XANES). Functional nanoparticles were further developed as new matrices for mass spectrometry by modification of α-cyano-4-hydroxycinnamic acid (CHCA) so that small molecular weight could be detected, which was hard to observe the spectra so far. We have detected small molecular analytes such as colchicin (MW=399.4Da) and aspirin (MW=180.1Da) using our developed functional nanoparticles. We have successfully developed new matrices for analytes in the low mass range without impurities. Finally, we aimed to detect 2-octynate methyl (2-OAm, MW=154.2Da), which is one of the important candidates for the triggering of primary biliary cirrhosis (PBC), a liver disease almost exclusively found in women. Our functional magnetic nanoparitlces are expected to contribute to the biomedical field.

Original languageEnglish
JournalSurface and Interface Analysis
DOIs
StateAccepted/In press - 2016

Fingerprint

Nanoparticles
Mass spectrometry
Molecules
X ray absorption
Iron oxides
Liver
Fourier transform infrared spectroscopy
Magnetization
Molecular weight
Impurities
X ray diffraction
Acids

Keywords

  • Functionalization
  • Iron oxcide
  • Mass spectrometry
  • Matrix
  • Nanoparticles

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Chemistry
  • Surfaces, Coatings and Films

Cite this

Preparation and characterization of newly developed matrix using functional γ-Fe2O3 nanoparticles for mass spectrometry in small molecules. / Morimoto, Shota; Ishikawa, Tomoya; Hyodo, Kuminori; Yamazaki, Takahiro; Taira, Shu; Tsuneyama, Koichi; Ichiyanagi, Yuko.

In: Surface and Interface Analysis, 2016.

Research output: Contribution to journalArticle

Morimoto, Shota; Ishikawa, Tomoya; Hyodo, Kuminori; Yamazaki, Takahiro; Taira, Shu; Tsuneyama, Koichi; Ichiyanagi, Yuko / Preparation and characterization of newly developed matrix using functional γ-Fe2O3 nanoparticles for mass spectrometry in small molecules.

In: Surface and Interface Analysis, 2016.

Research output: Contribution to journalArticle

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AU - Ichiyanagi,Yuko

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AB - Iron oxide magnetic nanoparticles were prepared by our original chemical wet method. These particles were functionalized by modification of amino groups and other molecules for biomedical application. The obtained particles were characterized by X-ray diffraction, fourier transform infrared spectroscopy (FT-IR), and magnetization measurements, and then local structures were analyzed using X-ray absorption near edge structure (XANES). Functional nanoparticles were further developed as new matrices for mass spectrometry by modification of α-cyano-4-hydroxycinnamic acid (CHCA) so that small molecular weight could be detected, which was hard to observe the spectra so far. We have detected small molecular analytes such as colchicin (MW=399.4Da) and aspirin (MW=180.1Da) using our developed functional nanoparticles. We have successfully developed new matrices for analytes in the low mass range without impurities. Finally, we aimed to detect 2-octynate methyl (2-OAm, MW=154.2Da), which is one of the important candidates for the triggering of primary biliary cirrhosis (PBC), a liver disease almost exclusively found in women. Our functional magnetic nanoparitlces are expected to contribute to the biomedical field.

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