Mechanism of mammalian germ cell development: Toward assisted new reproductive technologies

Atsushi Suzuki, Yasuyuki Kurihara, Yumiko Saga

    Abstract

    Approximately 10% of Japanese couples who want to have children experience infertility, and the majority of these individuals have either abnormal egg cell or abnormal sperm development. In addition, currently, there is a low birth rate in many parts of the developed world; therefore, it is critical to elucidate the mechanisms of germ cell development. Thus, the study of assisted reproductive technologies has scientific significance, and is a key to solving infertility problems. This review summarizes the development of mouse germ cells, particularly focusing on the role of Nanos genes, which are essential for the development of mouse germ cells and have been identified as genes that are involved in human infertility. We also briefly introduce a study in which this information is applied to assisted reproductive technologies. © Japan Society for Reproductive Medicine 2011.

    Original languageEnglish
    Pages (from-to)73-77
    Number of pages5
    JournalReproductive Medicine and Biology
    Volume11
    Issue number2
    DOIs
    StatePublished - 2012 Apr 1

    Fingerprint

    Germ Cells
    Infertility
    Assisted Reproductive Techniques
    Reproductive Medicine
    Birth Rate
    Essential Genes
    Ovum
    Spermatozoa
    Genes

    Keywords

    • ART
    • Germ cells
    • Infertility
    • iPS
    • Mouse

    ASJC Scopus subject areas

    • Reproductive Medicine
    • Cell Biology

    Cite this

    Mechanism of mammalian germ cell development : Toward assisted new reproductive technologies. / Suzuki, Atsushi; Kurihara, Yasuyuki; Saga, Yumiko.

    In: Reproductive Medicine and Biology, Vol. 11, No. 2, 01.04.2012, p. 73-77.

    Research output: Contribution to journalArticle

    Suzuki, Atsushi; Kurihara, Yasuyuki; Saga, Yumiko / Mechanism of mammalian germ cell development : Toward assisted new reproductive technologies.

    In: Reproductive Medicine and Biology, Vol. 11, No. 2, 01.04.2012, p. 73-77.

    Research output: Contribution to journalArticle

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