Development of magneto-plasmonic nanoparticles for multimodal image-guided therapy to the brain

Asahi Tomitaka, Hamed Arami, Andrea Raymond, Adriana Yndart, Ajeet Kaushik, Rahul Dev Jayant, Yasushi Takemura, Yong Cai, Michal Toborek, Madhavan Nair

    Abstract

    Magneto-plasmonic nanoparticles are one of the emerging multi-functional materials in the field of nanomedicine. Their potential for targeting and multi-modal imaging is highly attractive. In this study, magnetic core/gold shell (MNP@Au) magneto-plasmonic nanoparticles were synthesized by citrate reduction of Au ions on magnetic nanoparticle seeds. Hydrodynamic size and optical properties of magneto-plasmonic nanoparticles synthesized with the variation of Au ions and reducing agent concentrations were evaluated. The synthesized magneto-plasmonic nanoparticles exhibited superparamagnetic properties, and their magnetic properties contributed to the concentration-dependent contrast in magnetic resonance imaging (MRI). The imaging contrast from the gold shell part of the magneto-plasmonic nanoparticles was also confirmed by X-ray computed tomography (CT). The transmigration study of the magneto-plasmonic nanoparticles using an in vitro blood-brain barrier (BBB) model proved enhanced transmigration efficiency without disrupting the integrity of the BBB, and showed potential to be used for brain diseases and neurological disorders.

    Original languageEnglish
    Pages (from-to)764-773
    Number of pages10
    JournalNanoscale
    Volume9
    Issue number2
    DOIs
    StatePublished - 2017 Jan 14

    Fingerprint

    Nanoparticles
    Imaging techniques
    Brain
    Gold
    Ions
    Medical nanotechnology
    Magnetic cores
    Functional materials
    Reducing agents
    Magnetic resonance
    Tomography
    Seed
    Magnetic properties
    Hydrodynamics
    Optical properties
    X rays

    ASJC Scopus subject areas

    • Materials Science(all)

    Cite this

    Tomitaka, A., Arami, H., Raymond, A., Yndart, A., Kaushik, A., Jayant, R. D., ... Nair, M. (2017). Development of magneto-plasmonic nanoparticles for multimodal image-guided therapy to the brain. Nanoscale, 9(2), 764-773. DOI: 10.1039/c6nr07520g

    Development of magneto-plasmonic nanoparticles for multimodal image-guided therapy to the brain. / Tomitaka, Asahi; Arami, Hamed; Raymond, Andrea; Yndart, Adriana; Kaushik, Ajeet; Jayant, Rahul Dev; Takemura, Yasushi; Cai, Yong; Toborek, Michal; Nair, Madhavan.

    In: Nanoscale, Vol. 9, No. 2, 14.01.2017, p. 764-773.

    Research output: Contribution to journalArticle

    Tomitaka, A, Arami, H, Raymond, A, Yndart, A, Kaushik, A, Jayant, RD, Takemura, Y, Cai, Y, Toborek, M & Nair, M 2017, 'Development of magneto-plasmonic nanoparticles for multimodal image-guided therapy to the brain' Nanoscale, vol 9, no. 2, pp. 764-773. DOI: 10.1039/c6nr07520g
    Tomitaka A, Arami H, Raymond A, Yndart A, Kaushik A, Jayant RD et al. Development of magneto-plasmonic nanoparticles for multimodal image-guided therapy to the brain. Nanoscale. 2017 Jan 14;9(2):764-773. Available from, DOI: 10.1039/c6nr07520g

    Tomitaka, Asahi; Arami, Hamed; Raymond, Andrea; Yndart, Adriana; Kaushik, Ajeet; Jayant, Rahul Dev; Takemura, Yasushi; Cai, Yong; Toborek, Michal; Nair, Madhavan / Development of magneto-plasmonic nanoparticles for multimodal image-guided therapy to the brain.

    In: Nanoscale, Vol. 9, No. 2, 14.01.2017, p. 764-773.

    Research output: Contribution to journalArticle

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