Acetylation of Prrp K150 regulates the subcellular localization

Kenta Sasaki, Atsushi Suzuki, Satoshi Kagatsume, Mana Ono, Katsuhiko Matsuzawa, Yusuke Taguchi, Yasuyuki Kurihara

    • 6 Citations

    Abstract

    Posttranslational modifications of proteins have profound effects on many aspects of their function and have received much attention due to the importance of these processes in epigenetic regulation. In this study, we report that deleted azoospermia associated protein 1 (DAZAP1)/proline-rich RNA binding protein (Prrp), a multifunctional RNA binding protein which is essential for spermatogenesis and normal cell growth, is acetylated at Lysine 150 within its RNA binding domain. The acetylation is predominantly observed in nuclear Prrp, and the nonacetylated form is in cytoplasm. Considering that Prrp is a shuttling protein, we suggest that the acetylation cycle at Prrp K150 regulates nucleocytoplasmic transport in cells. © 2011 Elsevier B.V.

    Original languageEnglish
    Pages (from-to)13-19
    Number of pages7
    JournalGene
    Volume491
    Issue number1
    DOIs
    StatePublished - 2012 Jan 1

    Fingerprint

    RNA-Binding Proteins
    Acetylation
    Proline
    Proteins
    Genetic Epigenesis
    Cell Nucleus Active Transport
    Spermatogenesis
    Post Translational Protein Processing
    Lysine
    Cytoplasm
    RNA

    Keywords

    • Acetylation
    • Germ cells
    • Nucleocytoplasmic transport
    • RNA binding protein

    ASJC Scopus subject areas

    • Genetics

    Cite this

    Sasaki, K., Suzuki, A., Kagatsume, S., Ono, M., Matsuzawa, K., Taguchi, Y., & Kurihara, Y. (2012). Acetylation of Prrp K150 regulates the subcellular localization. Gene, 491(1), 13-19. DOI: 10.1016/j.gene.2011.09.022

    Acetylation of Prrp K150 regulates the subcellular localization. / Sasaki, Kenta; Suzuki, Atsushi; Kagatsume, Satoshi; Ono, Mana; Matsuzawa, Katsuhiko; Taguchi, Yusuke; Kurihara, Yasuyuki.

    In: Gene, Vol. 491, No. 1, 01.01.2012, p. 13-19.

    Research output: Contribution to journalArticle

    Sasaki, K, Suzuki, A, Kagatsume, S, Ono, M, Matsuzawa, K, Taguchi, Y & Kurihara, Y 2012, 'Acetylation of Prrp K150 regulates the subcellular localization' Gene, vol 491, no. 1, pp. 13-19. DOI: 10.1016/j.gene.2011.09.022
    Sasaki K, Suzuki A, Kagatsume S, Ono M, Matsuzawa K, Taguchi Y et al. Acetylation of Prrp K150 regulates the subcellular localization. Gene. 2012 Jan 1;491(1):13-19. Available from, DOI: 10.1016/j.gene.2011.09.022

    Sasaki, Kenta; Suzuki, Atsushi; Kagatsume, Satoshi; Ono, Mana; Matsuzawa, Katsuhiko; Taguchi, Yusuke; Kurihara, Yasuyuki / Acetylation of Prrp K150 regulates the subcellular localization.

    In: Gene, Vol. 491, No. 1, 01.01.2012, p. 13-19.

    Research output: Contribution to journalArticle

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    AU - Taguchi,Yusuke

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    AB - Posttranslational modifications of proteins have profound effects on many aspects of their function and have received much attention due to the importance of these processes in epigenetic regulation. In this study, we report that deleted azoospermia associated protein 1 (DAZAP1)/proline-rich RNA binding protein (Prrp), a multifunctional RNA binding protein which is essential for spermatogenesis and normal cell growth, is acetylated at Lysine 150 within its RNA binding domain. The acetylation is predominantly observed in nuclear Prrp, and the nonacetylated form is in cytoplasm. Considering that Prrp is a shuttling protein, we suggest that the acetylation cycle at Prrp K150 regulates nucleocytoplasmic transport in cells. © 2011 Elsevier B.V.

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