Abolition of the hippocampal theta activity and drug-learning dissociation

Naoki Irisawa, Shinkuro Iwahara, Sachio Fukuda

  • 1 Citations

Abstract

Rats were trained to escape electric shock by running into one arm of a T-maze on 10-trial daily sessions with pentobarbital (10mg/kg), and to the opposite arm of the maze on other sessions with saline, the drug and saline sessions being alternated. This drug-learning dissociation or state-dependent learning was achieved by rats with medial septal lesions, abolishing hippocampal theta activity, as efficiently as rats with cortical lesions and intact rats. The suggested relationship between drug-learning dissociation and the suppression of hippocampal theta waves, produced by the drug, was not evidenced. © 1976 Springer-Verlag.

Original languageEnglish
Pages (from-to)203-204
Number of pages2
JournalPsychopharmacology
Volume47
Issue number2
DOIs
StatePublished - 1976 Jun 1
Externally publishedYes

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Pentobarbital

Keywords

  • Drug-learning dissociation
  • Drug-state dependency
  • Hippocampal theta activity
  • Medial septal lesions
  • Pentobarbital

ASJC Scopus subject areas

  • Pharmacology

Cite this

Abolition of the hippocampal theta activity and drug-learning dissociation. / Irisawa, Naoki; Iwahara, Shinkuro; Fukuda, Sachio.

In: Psychopharmacology, Vol. 47, No. 2, 01.06.1976, p. 203-204.

Research output: Contribution to journalArticle

Irisawa, N, Iwahara, S & Fukuda, S 1976, 'Abolition of the hippocampal theta activity and drug-learning dissociation' Psychopharmacology, vol 47, no. 2, pp. 203-204. DOI: 10.1007/BF00735823
Irisawa N, Iwahara S, Fukuda S. Abolition of the hippocampal theta activity and drug-learning dissociation. Psychopharmacology. 1976 Jun 1;47(2):203-204. Available from, DOI: 10.1007/BF00735823

Irisawa, Naoki; Iwahara, Shinkuro; Fukuda, Sachio / Abolition of the hippocampal theta activity and drug-learning dissociation.

In: Psychopharmacology, Vol. 47, No. 2, 01.06.1976, p. 203-204.

Research output: Contribution to journalArticle

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