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Research Output 1980 2016

  • 875 Citations
  • 17 h-Index
  • 37 Article
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Article
2016
2 Citations

Tributyltin induces G2/M cell cycle arrest via NAD+-dependent isocitrate dehydrogenase in human embryonic carcinoma cells

Asanagi, M., Yamada, S., Hirata, N., Itagaki, H., Kotake, Y., Sekino, Y. & Kanda, Y. 2016 Mar 10 In : Journal of Toxicological Sciences. 41, 2, p. 207-215 9 p.

Research output: Contribution to journalArticle

G2 Phase Cell Cycle Checkpoints
Isocitrate Dehydrogenase
NAD
Carcinoma
Cell Cycle
1 Citations

Tributyltin induces mitochondrial fission through Mfn1 degradation in human induced pluripotent stem cells

Yamada, S., Asanagi, M., Hirata, N., Itagaki, H., Sekino, Y. & Kanda, Y. 2016 Aug 1 In : Toxicology in Vitro. 34, p. 257-263 7 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Induced Pluripotent Stem Cells
Stem Cells
Membranes
Organotin Compounds
2015

Anaphylactic augmentation by epicutaneous sensitization to acid-hydrolyzed wheat protein in a guinea pig model

Matsunaga, K., Kuroda, Y., Sakai, S., Adachi, R., Teshima, R., Yagami, A. & Itagaki, H. 2015 Nov 10 In : Journal of Toxicological Sciences. 40, 6, p. 745-752 8 p.

Research output: Contribution to journalArticle

Glutens
Triticum
Guinea Pigs
Acids
Proteins
1 Citations
Local Lymph Node Assay
Ear
Lymph Nodes
Skin
Dinitrochlorobenzene

Unsaturated fatty acids show clear elicitation responses in a modified local lymph node assay with an elicitation phase, and test positive in the direct peptide reactivity assay

Yamashita, K., Shinoda, S., Hagiwara, S., Miyazaki, H. & Itagaki, H. 2015 Nov 10 In : Journal of Toxicological Sciences. 40, 6, p. 843-853 11 p.

Research output: Contribution to journalArticle

Local Lymph Node Assay
Unsaturated Fatty Acids
Peptides
Skin
Acids
2014
3 Citations
Local Lymph Node Assay
Ear
Dinitrofluorobenzene
Skin
Benzoquinones
2010
51 Citations

A comparative evaluation of in vitro skin sensitisation tests: The human cell-line activation test (h-CLAT) versus the Local Lymph Node Assay (LLNA)

Ashikaga, T., Sakaguchi, H., Sono, S., Kosaka, N., Ishikawa, M., Nukada, Y., Miyazawa, M., Ito, Y., Nishiyama, N. & Itagaki, H. 2010 Dec 1 In : ATLA Alternatives to Laboratory Animals. 38, 4, p. 275-284 10 p.

Research output: Contribution to journalArticle

Skin Tests
Cell Line
In Vitro Techniques
Local Lymph Node Assay
Benzoyl Peroxide
5 Citations

Changes of cell-surface thiols and intracellular signaling in human monocytic cell line THP-1 treated with diphenylcyclopropenone

Hirota, M., Motoyama, A., Suzuki, M., Yanagi, M., Kitagaki, M., Kouzuki, H., Hagino, S., Itagaki, H., Sasa, H., Kagatani, S. & Aiba, S. 2010 Dec 1 In : Journal of Toxicological Sciences. 35, 6, p. 871-879 9 p.

Research output: Contribution to journalArticle

Sulfhydryl Compounds
Cell Line
Endoplasmic Reticulum Stress
Glutathione Disulfide
Proteins
1 Citations

Further verification of an in vitro tier system for the identification of cosmetic ingredients that are not ocular irritants

Hagino, S., Okazaki, Y., Kitagaki, M. & Itagaki, H. 2010 May 1 In : ATLA Alternatives to Laboratory Animals. 38, 2, p. 139-152 14 p.

Research output: Contribution to journalArticle

Irritants
Cosmetics
In Vitro Techniques
Cell Culture Techniques
Rabbits
20 Citations

Oxidation of cell surface thiol groups by contact sensitizers triggers the maturation of dendritic cells

Kagatani, S., Sasaki, Y., Hirota, M., Mizuashi, M., Suzuki, M., Ohtani, T., Itagaki, H. & Aiba, S. 2010 Jan 1 In : Journal of Investigative Dermatology. 130, 1, p. 175-183 9 p.

Research output: Contribution to journalArticle

Sulfhydryl Compounds
Dendritic Cells
Monocytes
p38 Mitogen-Activated Protein Kinases
Messenger RNA
2009
13 Citations

Development of an in vitro photosensitization assay using human monocyte-derived cells

Hoya, M., Hirota, M., Suzuki, M., Hagino, S., Itagaki, H. & Aiba, S. 2009 Aug 1 In : Toxicology in Vitro. 23, 5, p. 911-918 8 p.

Research output: Contribution to journalArticle

Photosensitivity Disorders
Monocytes
In Vitro Techniques
Irritants
Reactive Oxygen Species
20 Citations

Evaluation of changes of cell-surface thiols as a new biomarker for in vitro sensitization test

Suzuki, M., Hirota, M., Hagino, S., Itagaki, H. & Aiba, S. 2009 Jun 1 In : Toxicology in Vitro. 23, 4, p. 687-696 10 p.

Research output: Contribution to journalArticle

Sulfhydryl Compounds
Biological Markers
In Vitro Techniques
Haptens
Allergens
17 Citations

Modification of cell-surface thiols elicits activation of human monocytic cell line THP-1: Possible involvement in effect of haptens 2,4- dinitrochlorobenzene and nickel sulfate

Hirota, M., Suzuki, M., Hagino, S., Kagatani, S., Sasaki, Y., Aiba, S. & Itagaki, H. 2009 Apr 1 In : Journal of Toxicological Sciences. 34, 2, p. 139-150 12 p.

Research output: Contribution to journalArticle

Sulfhydryl Compounds
Cell Line
Dinitrochlorobenzene
p38 Mitogen-Activated Protein Kinases
Dithionitrobenzoic Acid
48 Citations

The relationship between CD86/CD54 expression and THP-1 cell viability in an in vitro skin sensitization test - Human cell line activation test (h-CLAT)

Sakaguchi, H., Ashikaga, T., Miyazawa, M., Kosaka, N., Ito, Y., Yoneyama, K., Sono, S., Itagaki, H., Toyoda, H. & Suzuki, H. 2009 Apr 1 In : Cell Biology and Toxicology. 25, 2, p. 109-126 18 p.

Research output: Contribution to journalArticle

Skin Tests
Cell Survival
Cell Line
In Vitro Techniques
Allergens
2008
11 Citations

An in vitro tier evaluation for the identification of cosmetic ingredients which are not ocular irritants

Hagino, S., Okazaki, Y. & Itagaki, H. 2008 Dec 1 In : ATLA Alternatives to Laboratory Animals. 36, 6, p. 641-652 12 p.

Research output: Contribution to journalArticle

Irritants
Cosmetics
Skin
In Vitro Techniques
Cell Culture Techniques
2006
124 Citations

Development of an in vitro skin sensitization test using human cell lines: The human Cell Line Activation Test (h-CLAT). I. Optimization of the h-CLAT protocol

Ashikaga, T., Yoshida, Y., Hirota, M., Yoneyama, K., Itagaki, H., Sakaguchi, H., Miyazawa, M., Ito, Y., Suzuki, H. & Toyoda, H. 2006 Aug 1 In : Toxicology in Vitro. 20, 5, p. 767-773 7 p.

Research output: Contribution to journalArticle

Skin Tests
Cell Line
In Vitro Techniques
Dinitrochlorobenzene
Inhibitory Concentration 50
118 Citations

Development of an in vitro skin sensitization test using human cell lines; human Cell Line Activation Test (h-CLAT) II. An inter-laboratory study of the h-CLAT

Sakaguchi, H., Ashikaga, T., Miyazawa, M., Yoshida, Y., Ito, Y., Yoneyama, K., Hirota, M., Itagaki, H., Toyoda, H. & Suzuki, H. 2006 Aug 1 In : Toxicology in Vitro. 20, 5, p. 774-784 11 p.

Research output: Contribution to journalArticle

Skin Tests
Cell Line
In Vitro Techniques
Allergens
Skin
58 Citations

Quantitative measurement of spliced XBP1 mRNA as an indicator of endoplasmic reticulum stress

Hirota, M., Kitagaki, M., Itagaki, H. & Aiba, S. 2006 Jun 22 In : Journal of Toxicological Sciences. 31, 2, p. 149-156 8 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Messenger RNA
Unfolded Protein Response
Protein Unfolding
Endoplasmic Reticulum
9 Citations

SIRC-CVS cytotoxicity test: An alternative for predicting rodent acute systemic toxicity

Kitagaki, M., Wakuri, S., Hirota, M., Tanaka, N. & Itagaki, H. 2006 Oct 1 In : Journal of Toxicological Sciences. 31, 4, p. 371-379 9 p.

Research output: Contribution to journalArticle

In Vitro Techniques
Rodentia
Chemical Databases
Gentian Violet
Poisons
2002
66 Citations

Evaluation of CD86 expression and MHC class II molecule internalization in THP-1 human monocyte cells as predictive endpoints for contact sensitizers

Ashikaga, T., Hoya, M., Itagaki, H., Katsumura, Y. & Aiba, S. 2002 Dec 1 In : Toxicology in Vitro. 16, 6, p. 711-716 6 p.

Research output: Contribution to journalArticle

Monocytes
Dinitrochlorobenzene
Irritants
Dendritic Cells
Sulfates
22 Citations

Utility of MTT assay in three-dimensional cultured human skin model as an alternative for Draize skin irritation test: Approach using diffusion law of irritant in skin and toxicokinetics-toxicodynamics correlation

Watanabe, T., Hasegawa, T., Takahashi, H., Ishibashi, T., Itagaki, H. & Sugibayashi, K. 2002 Jun 4 In : Pharmaceutical Research. 19, 5, p. 669-675 7 p.

Research output: Contribution to journalArticle

Skin Tests
Skin
Cetylpyridinium
Guinea Pigs
Irritants
1999
53 Citations

Interlaboratory validation of the in vitro eye irritation tests for cosmetic ingredients. (1) Overview of the validation study and Draize scores for the evaluation of the tests

Itakagaki, H. & 30 others Ohno, Y., Kaneko, T., Inoue, T., Morikawa, Y., Yoshida, T., Fujii, A., Masuda, M., Ohno, T., Hayashi, M., Momma, J., Uchiyama, T., Chiba, K., Ikeda, N., Imanishi, Y., Kakishima, H., Kasai, Y., Kurishita, A., Kojima, H., Matsukawa, K., Nakamura, T., Ohkoshi, K., Okumura, H., Saijo, K., Sakamoto, K., Suzuki, T., Takano, K., Tatsumi, H., Tani, N., Usami, M. & Watanabe, R. 1999 Feb 1 In : Toxicology in Vitro. 13, 1, p. 73-98 26 p.

Research output: Contribution to journalArticle

Validation Studies
Cosmetics
In Vitro Techniques
Chorioallantoic Membrane
Trypan Blue
21 Citations

Interlaboratory validation of the in vitro eye irritation tests for cosmetic ingredients. (3) Evaluation of the haemolysis test

Okamoto, Y., Ohkoshi, K., Itagaki, H., Tsuda, T., Kakishima, H., Ogawa, T., Kasai, Y., Ohuchi, J., Kojima, H., Kurishita, A., Kaneko, T., Matsushima, Y., Iwabuchi, Y. & Ohno, Y. 1999 Feb 1 In : Toxicology in Vitro. 13, 1, p. 115-124 10 p.

Research output: Contribution to journalArticle

Hemolysis
Cosmetics
In Vitro Techniques
Irritants
Hemoglobins
22 Citations

Interlaboratory validation of the in vitro eye irritation tests for cosmetic ingredients. (8) Evaluation of cytotoxicity tests on SIRC cells

Tani, N., Kinoshita, S., Okamoto, Y., Kotani, M., Itagaki, H., Murakami, N., Sugiura, S., Usami, M., Kato, K., Kojima, H., Ohno, T., Saijo, K., Kato, M., Hayashi, M. & Ohno, Y. 1999 Feb 1 In : Toxicology in Vitro. 13, 1, p. 175-187 13 p.

Research output: Contribution to journalArticle

Gentian Violet
Cosmetics
Staining and Labeling
In Vitro Techniques
Neutral Red
1997
7 Citations

Interleukin-1α and Interleukin-8 Release by Human Keratinocyte Cell Culture Treated with Surfactants

Shibata, M., Tsuda, T., Itagaki, H., Kato, S., Kobayashi, T., Ichikawa, H. & Morikawa, Y. 1997 Mar 1 In : ATLA Alternatives to Laboratory Animals. 25, 2, p. 161-171 11 p.

Research output: Contribution to journalArticle

Interleukin-8
Keratinocytes
Surface-Active Agents
Cell Culture Techniques
Betaine
1996
4 Citations

Evaluation of stinging-inducing chemicals using cultured neuronal cells: An electrophysiological approach

Inoue, K., Nakazawa, K., Inoue, K., Fujimori, K., Ohno, Y., Takanaka, A., Itagaki, H., Kato, S., Kobayashi, T. & Kuroiwa, Y. 1996 Aug In : Toxicology in Vitro. 10, 4, p. 455-462 8 p.

Research output: Contribution to journalArticle

PC12 Cells
Cultured Cells
Spinal Ganglia
Cosmetics
Neurons
1995
12 Citations

Hemoglobin denaturation caused by surfactants

Hayashi, T., Itagaki, H., Fukuda, T., Tamura, U., Sato, Y. & Suzuki, Y. 1995 Jan 1 In : Biological and Pharmaceutical Bulletin. 18, 4, p. 540-543 4 p.

Research output: Contribution to journalArticle

Surface-Active Agents
Hemoglobins
Sodium
Spectrophotometry
Circular Dichroism
9 Citations

Validation study on five different cytotoxicity assays in Japan-an intermediate report

Ohno, T., Itagaki, H., Tanaka, N. & Ono, H. 1995 Jan 1 In : Toxicology in Vitro. 9, 4, p. 571-576 6 p.

Research output: Contribution to journalArticle

Validation Studies
Cetylpyridinium
Gentian Violet
Neutral Red
Irritants
1994
7 Citations

Multivariate factorial analysis of data obtained in seven in vitro test systems for predicting eye irritancy

Hayashi, T., Itagaki, H., Fukuda, T., Tamura, U. & Kato, S. 1994 Jan 1 In : Toxicology in Vitro. 8, 2, p. 215-220 6 p.

Research output: Contribution to journalArticle

Protein Denaturation
Hemoglobins
Multivariate Analysis
In Vitro Techniques
Cell Membrane
1993
15 Citations

Further evaluation of the quantitative chorioallantoic membrane test using trypan blue stain to predict the eye irritancy of chemicals

Hagino, S., Itagaki, H., Kato, S. & Kobayashi, T. 1993 Jan 1 In : Toxicology in Vitro. 7, 1, p. 35-39 5 p.

Research output: Contribution to journalArticle

Chorioallantoic Membrane
Trypan Blue
Coloring Agents
Staining and Labeling
Emulsions
1991
35 Citations

An in vitro alternative to the Draize eye-irritation test: Evaluation of the crystal violet staining method

Itagaki, H., Hagino, S., Kato, S., Kobayashi, T. & Umeda, M. 1991 Jan 1 In : Toxicology in Vitro. 5, 2, p. 139-143 5 p.

Research output: Contribution to journalArticle

In Vitro Techniques
Gentian Violet
Surface-Active Agents
HeLa Cells
Staining and Labeling
23 Citations

Quantitative evaluation to predict the eye irritancy of chemicals: Modification of chorioallantoic membrane test by using trypan blue

Hagino, S., Itagaki, H., Kato, S., Kobayashi, T. & Tanaka, M. 1991 Jan 1 In : Toxicology in Vitro. 5, 4, p. 301-304 4 p.

Research output: Contribution to journalArticle

Chorioallantoic Membrane
Trypan Blue
Eggs
Staining and Labeling
1988
11 Citations

Liposomes as an in vitro model for predicting the eye irritancy of chemicals

Kato, S., Itagaki, H., Chiyoda, I., Hagino, S., Kobayashi, T., Fujiyama, Y., Kakoki, H. & Yamaguchi, M. 1988 Jan 1 In : Toxicology in Vitro. 2, 2, p. 125-130 6 p.

Research output: Contribution to journalArticle

Liposomes
In Vitro Techniques
Hymecromone
Surface-Active Agents
Alkaline Phosphatase
1986
8 Citations

Role of a metabolite in allergenicity of Sudan I

Kato, S., Itagaki, H. & Uchiyama, M. 1986 Dec 1 In : Contact Dermatitis. 15, 4, p. 205-210 6 p.

Research output: Contribution to journalArticle

Sudan
Naphthols
Guinea Pigs
Hydroxylation
Gas Chromatography-Mass Spectrometry
1983
6 Citations

Drug sensor: An enzyme immunoelectrode for theophylline

Itagaki, H., Hakoda, Y., Suzuki, Y. & Haga, M. 1983 Jan 1 In : Chemical and Pharmaceutical Bulletin. 31, 4, p. 1283-1288 6 p.

Research output: Contribution to journalArticle

1981
32 Citations

Drug sensor: Liposome immunosensor for theophylline

Haga, M., Sugawara, S. & Itagaki, H. 1981 Jan 1 In : Analytical Biochemistry. 118, 2, p. 286-293 8 p.

Research output: Contribution to journalArticle

Liposomes
Theophylline
Electrodes
Theobromine
Antigen-Antibody Reactions
1980
20 Citations

Liposome immunosensor for theophylline

Haga, M., Itagaki, H., Sugawara, S. & Okano, T. 1980 Jan 1 In : Biochemical and Biophysical Research Communications. 95, 1, p. 187-192 6 p.

Research output: Contribution to journalArticle

Theophylline
Liposomes